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Gilespox was a "disease" which second and third year Giles girls attempted to give members of their own dorms, other dorms, and RCs during Quadfest '06, East Term II. Gilespox began when the girls accidentally infected themselves by smearing green dots on their arms. Spreading Gilespox soon became a game; they would infect members of Alspaugh and Pegram by smearing paint on them when they weren't looking, and then run away.

Other members of Giles dorm got their revenge on those spreading the disease by smearing more paint on them, turning the dots into large blobs of paint. Thus many cases of Gilespox escalated into cases of Gilessores.

Most everyone recovered following Quadfest, though the disgusting TiPsters who refused to shower afterwards remained ill.